Steroid-transporting ATPase
Steroid-transporting ATPase (EC 3.6.3.45, pleiotropic-drug-resistance protein, PDR protein) is an enzyme with systematic name ATP phosphohydrolase (steroid-exporting).[1][2][3] This enzyme catalyses the following chemical reaction
- ATP + H2O + steroidin ADP + phosphate + steroidout
| Steroid-transporting ATPase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.6.3.45 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
This enzyme has two similar ATP-binding domains.
References
- Prasad R, De Wergifosse P, Goffeau A, Balzi E (March 1995). "Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals". Current Genetics. 27 (4): 320–9. doi:10.1007/BF00352101. PMID 7614555.
- Nagao K, Taguchi Y, Arioka M, Kadokura H, Takatsuki A, Yoda K, Yamasaki M (March 1995). "bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily". Journal of Bacteriology. 177 (6): 1536–43. PMC 176770. PMID 7883711.
- Mahé Y, Lemoine Y, Kuchler K (October 1996). "The ATP binding cassette transporters Pdr5 and Snq2 of Saccharomyces cerevisiae can mediate transport of steroids in vivo". The Journal of Biological Chemistry. 271 (41): 25167–72. doi:10.1074/jbc.271.41.25167. PMID 8810273.
External links
- Steroid-transporting+ATPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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