Poly(ADP-ribose) glycohydrolase

Poly(ADP-ribose) glycohydrolase (EC 3.2.1.143) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

hydrolyses poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose
Poly(ADP-ribose) glycohydrolase
Identifiers
EC no.3.2.1.143
CAS no.9068-16-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
PubMedarticles
NCBIproteins

Specific to (1''-2') linkage of ribose-ribose bond of poly(ADP-ribose).

References

  1. Miwa M, Sugimura T (October 1971). "Splitting of the ribose-ribose linkage of poly(adenosine diphosphate-robose) by a calf thymus extract". The Journal of Biological Chemistry. 246 (20): 6362–4. PMID 4331388.
  2. Lin W, Amé JC, Aboul-Ela N, Jacobson EL, Jacobson MK (May 1997). "Isolation and characterization of the cDNA encoding bovine poly(ADP-ribose) glycohydrolase". The Journal of Biological Chemistry. 272 (18): 11895–901. doi:10.1074/jbc.272.18.11895. PMID 9115250.
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