Professor X in other media

Professor Xavier, played by both James McAvoy (left) and Patrick Stewart (right) in X-Men: Days of Future Past (2014), in an iconic scene where the two iterations of the character meet.

Xavier has appeared in eleven live-action feature films to date. He is played by Patrick Stewart in the X-Men films X-Men, X2, X-Men: The Last Stand, X-Men Origins: Wolverine, The Wolverine, and Logan and the Marvel Cinematic Universe (MCU) film Doctor Strange in the Multiverse of Madness, and by James McAvoy in X-Men: First Class, X-Men: Apocalypse, Deadpool 2 and Dark Phoenix. Both actors play him at different time-periods in X-Men: Days of Future Past. It is implied that Xavier is one of the most powerful mutants in the world. Although Xavier is American-born in the comics and in animation, he speaks with a British accent in the films (although First Class establishes that he lived in the United States during childhood, though he may have picked up the accent from his English mother).

The X-Men novel "Shadows of the Past" by Michael Jan Friedman (set in the continuity of the comics) opens with Xavier attending the funeral of one of his old professors, Jeremiah Saunders, only to be captured on the way back to the mansion by the forces of his old adversary Lucifer, who replaces Xavier with a duplicate of himself made of ionic energy, possessing Xavier's powers and memories but programmed to be loyal to Lucifer. Other ionic constructs use equipment in a Quistalium facility on Earth to transfer Xavier into the Nameless Dimension where Lucifer has been imprisoned since one of his last attacks on Earth, the Nameless Dimension being a strange void full of 'liquid' that Xavier and Lucifer can breathe as though it is still oxygen. Lucifer intends to use the duplicate Xavier to retrieve key devices from other Quistalium outposts on Earth that can be used to modify the equipment that transferred Xavier to the Nameless Dimension, reconfiguring it so that Lucifer will be able to escape back into this world, assigning that task to the original five X-Men while claiming that the device is to be used as part of a machine that 'Xavier' has created to protect Earth from future invasion. Xavier is able to telepathically reach beyond the Nameless Dimension back to Earth, but cannot contact the X-Men as his telepathic powers are too weak to make contact with them amid their complex thoughts across the dimensional barrier. Fortunately, Xavier is able to contact Jeffrey Saunders, Jeremiah's grandson, who possesses a brain defect that hampers his ability to process information, Jeffrey's physically superior body allowing Xavier to travel to the mansion and expose his duplicate as a fake. With the X-Men alerted to Lucifer's deception, they are able to use the equipment to retrieve Xavier from the Nameless Dimension before destroying it, trapping Lucifer all over again.

In the X-Men/Star Trek crossover novel Planet X, Archangel and Beverly Crusher program a copy of Professor X into the holodeck of the Enterprise-E based on Archangel's own knowledge of the professor and information the Enterprise downloaded from the Xavier Mansion's computers during their visit to the Marvel Universe. Crusher privately reflects that Professor X and Captain Picard look surprisingly similar, with the two sharing the same thoughts when they later meet. Accepting his status as a hologram of himself, Xavier assists Doctor Crusher in developing a cure for the 'transformed', a group of artificially-created mutants on a planet that the Enterprise is visiting. In a later meeting with Picard, Xavier invites the captain to return and speak with him in the future if his personality will remain in the holodecks after the current crisis has been resolved, Picard assuring the Professor that he would be honoured to do so as he compliments Xavier's success in bringing the X-Men together given their diverse personalities and powers.

The Chaos Engine trilogy sees Xavier and a team of X-Men become aware that an initially-unknown force has rewritten their reality while they were in the Starlight Citadel, Roma allowing them time to restore their reality before she has to destroy it to prevent the corruption of the multiverse. After the X-Men- Cyclops, Jean Grey, Wolverine, Gambit, Rogue and Nightcrawler- learn that reality was reshaped by Doctor Doom using a flawed Cosmic Cube, Magneto acquires the Cube and uses it to create his own perfect world, leaving Xavier with only Psylocke as an ally as Jean was able to restore Psylocke's memories of the true reality before the reset. Xavier is able to convince Magneto that he cannot use the Cube this way without destroying everything, but the two are attacked by the Red Skull before they can restore the real world. In this new reality, Xavier is a willing traitor to his own kind, using his abilities to identify and expose mutants to the Nazi rulers of Earth in exchange for his own freedom. Fortunately, various X-Men are able to restore their original personas and turn the tables on the Skull, allowing them to return reality to normal.[4]

Professor X appears in most of the X-Men video games.

• He is almost always an NPC and advises the X-Men on various missions in the role playing games.
• In the case of the fighting games, he appears in some of the characters' endings. In Marvel vs. Capcom, he is possessed by Onslaught, the game's final boss.
• He appears in the X-Men: Mutant Academy game for the Sony PlayStation, helping the player in Academy Mode.
• He appears in the X-Men: Mutant Academy 2 game for the Sony PlayStation, as an unlockable playable character.
• He appears in the training modes for Spider-Man 2: Enter Electro, voiced by Daran Norris.[1]
• Professor X appeared in X2: Wolverine's Revenge, with Patrick Stewart reprising his role.[1]
• Xavier is also a playable character in the game X-Men Legends, and its sequel X-Men Legends II: Rise of Apocalypse (in the first game, he is playable in one level and when all danger room discs are completed; in the second, he is playable once all the Danger Room missions are completed. He also appears as a major NPC in both games). Patrick Stewart voices Xavier in both Legends games.[1] When playable, he is seen without his wheelchair.
• Professor X appeared in X-Men: The Official Game, with Patrick Stewart reprising his role.[1]
• Professor X appears as an NPC in the game Marvel: Ultimate Alliance, voiced by Tom Kane.[1] He helps the heroes by using Cerebro to locate Nightcrawler and Jean Grey. He is amongst the heroes who are defeated by Doctor Doom and seen on the ground next to Magneto with his wheelchair demolished. Also in the game, if the player chooses to save Jean Grey from being dropped into the Infinity Vortex, Mystique will avenge Nightcrawler by infiltrating the X-Mansion at night to vent her frustration upon Professor X where he will die in a coma months later and his death will cause the X-Men to disband forever (Cyclops, Wolverine, and surprisingly Nightcrawler, are among the X-Men seen surrounding his grave). Professor X has special dialogue with Iceman, Wolverine, Storm, and Magneto.
• He is briefly mentioned by Lisa Simpson in The Simpsons Game concerning the families' powers.
• Professor X appears in the PlayStation 2 and version of Spider-Man: Web of Shadows. He appears as an assist character who uses his telepathy upon the enemies.
• In X-Men: Destiny, it is revealed that Professor X is dead as there is a memorial for him at the beginning of the game.
• Professor X appears in Marvel: Avengers Alliance. He appears as a non-playable character in Season 2.
• Professor X appeared as a playable character in Lego Marvel Super Heroes, voiced by James Arnold Taylor.[1][5] Wolverine brings the Tesseract to Professor X hoping that he would be able to unlock its secrets only for Magneto and the Brotherhood of Mutants to attack. One of the missions he gives to the players is to use a psychic character to guide a student through a maze.
• Professor X appeared in Marvel Heroes, with Jim Ward reprising his role.
• Professor X appears in the "Rise of the Phoenix" DLC of Marvel Ultimate Alliance 3: The Black Order, voiced by Keith Ferguson.[1]
• Professor X is introduced as a playable character in the mobile game Marvel: Future Fight as part of the House of X and Powers of X update. The character currently can only be purchased through Danger Room limited offers.[6]
• Professor X appears as a playable character in MOBA game Marvel Super War. His role is Support, his passive allows him to break enemy's resistance both physical and energy. He's also able to control an enemy with his telepathy. His ultimate skill is global scale, where he uses Cerebro to scan all enemies in battlefield, before putting them to sleep after set amount of time.