Pseudoviridae

Pseudoviridae is a family of viruses,[1] which includes three genera.[2]

Pseudoviridae
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Pararnavirae
Phylum: Artverviricota
Class: Revtraviricetes
Order: Ortervirales
Family: Pseudoviridae
Genera
Reconstruction of Saccharomyces cerevisiae Ty1 (genus Pseudovirus) virion with its building blocks.

Viruses of the family are actually LTR retrotransposons of the Ty1-copia family. They replicate via structures called virus-like particles (VLPs). VLPs are not infectious like normal virions, but they nevertheless make up an essential part of the pseudoviral lifecycle.[2]

Taxonomy

Pseudoviridae is unofficially classified under group VI RNA Reverse Transcribing Viruses and infect fungi and invertebrates.

Pseudoviridae comprises highly divergent members and most Pseudoviridae encode Gag and Pol on a single open reading frame.

Pseudoviridae is included in the order Ortervirales along with families Belpaoviridae, Metaviridae, Retroviridae, and Caulimoviridae.[3]

The family includes the following genera:[2]

Further Pseudoviridae species not classified into a genus are:

  • Penicillium camemberti virus - GP1[4]
  • Phaseolus vulgaris Tpv2-6 virus

Genome
Genome map of Saccharomyces cerevisiae Ty1 virus

The genome of viruses from this family is unsegmented, -RT, positive-sense, single-stranded RNA and is 4200–9700 nucleotides long. The genome encodes structural proteins and non-structural proteins which codes for an RNA-dependent DNA polymerase, replicase, and reverse transcriptase for the reverse transcription step during replication.

Virology

The viral capsid is unenveloped and looks roughly spherical. The capsid is round with icosahedral symmetry with triangulation number (T) = 3 and 4. It is also isometric to quasi-isometric and has a diameter of 30-50 nm. LTR-retrotransposons are poorly characterized and lipids have not reported.

The genome integrates into the host genome and gets transcribed by host cell enzymes such as eukaryotic nuclear RNA polymerase II. Genome replication takes place in the host cytoplasm, or the nucleus and assembly can occur in the cytoplasm, or in the nucleus.

References
  1. Llorens, C; Soriano, B; Krupovic, M; ICTV Report Consortium (2 February 2021). "ICTV Virus Taxonomy Profile: Pseudoviridae". The Journal of General Virology. 102 (3). doi:10.1099/jgv.0.001563. PMID 33528349.
  2. "ICTV Report Pseudoviridae".
  3. Krupovic M, Blomberg J, Coffin JM, Dasgupta I, Fan H, Geering AD, et al. (June 2018). "Ortervirales: New Virus Order Unifying Five Families of Reverse-Transcribing Viruses". Journal of Virology. 92 (12). doi:10.1128/JVI.00515-18. PMC 5974489. PMID 29618642.
  4. NCBI: Penicillium camemberti virus - GP1 (species)
This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.