RALGDS

Ral guanine nucleotide dissociation stimulator is a protein that is encoded by the RALGDS gene in humans.[5][6]

RALGDS
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRALGDS, RGDS, RGF, RalGEF, ral guanine nucleotide dissociation stimulator
External IDsOMIM: 601619 MGI: 107485 HomoloGene: 4562 GeneCards: RALGDS
Orthologs
SpeciesHumanMouse
Entrez

5900

19730

Ensembl

ENSG00000160271

ENSMUSG00000026821

UniProt

Q12967

Q03385

RefSeq (mRNA)

NM_006266
NM_001042368
NM_001271774
NM_001271775
NM_001271776

NM_001145834
NM_001145835
NM_001145836
NM_009058

RefSeq (protein)

NP_001035827
NP_001258703
NP_001258704
NP_001258705
NP_006257

NP_001139306
NP_001139307
NP_001139308
NP_033084

Location (UCSC)Chr 9: 133.1 – 133.15 MbChr 2: 28.4 – 28.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RALGDS has been shown to interact with:

References

  1. GRCh38: Ensembl release 89: ENSG00000160271 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000026821 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Hofer F, Fields S, Schneider C, Martin GS (December 1994). "Activated Ras interacts with the Ral guanine nucleotide dissociation stimulator". Proc Natl Acad Sci U S A. 91 (23): 11089–93. Bibcode:1994PNAS...9111089H. doi:10.1073/pnas.91.23.11089. PMC 45172. PMID 7972015.
  6. "Entrez Gene: RALGDS ral guanine nucleotide dissociation stimulator".
  7. Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (August 2002). "Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization". Nat. Cell Biol. 4 (8): 547–55. doi:10.1038/ncb821. PMID 12105416. S2CID 20784208.
  8. Spaargaren M, Bischoff JR (December 1994). "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras, and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609–13. Bibcode:1994PNAS...9112609S. doi:10.1073/pnas.91.26.12609. PMC 45488. PMID 7809086.
  9. Boettner B, Govek EE, Cross J, Van Aelst L (August 2000). "The junctional multidomain protein AF-6 is a binding partner of the Rap1A GTPase and associates with the actin cytoskeletal regulator profilin". Proc. Natl. Acad. Sci. U.S.A. 97 (16): 9064–9. Bibcode:2000PNAS...97.9064B. doi:10.1073/pnas.97.16.9064. PMC 16822. PMID 10922060.
  10. Li W, Han M, Guan KL (April 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. 14 (8): 895–900. doi:10.1101/gad.14.8.895. PMC 316541. PMID 10783161.
  11. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
  12. Miller MJ, Prigent S, Kupperman E, Rioux L, Park SH, Feramisco JR, White MA, Rutkowski JL, Meinkoth JL (February 1997). "RalGDS functions in Ras- and cAMP-mediated growth stimulation". J. Biol. Chem. 272 (9): 5600–5. doi:10.1074/jbc.272.9.5600. PMID 9038168.
  13. Rodriguez-Viciana P, Warne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A, Downward J (May 1997). "Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras". Cell. 89 (3): 457–67. doi:10.1016/s0092-8674(00)80226-3. PMID 9150145. S2CID 14459536.
  14. Stang S, Bottorff D, Stone JC (June 1997). "Interaction of activated Ras with Raf-1 alone may be sufficient for transformation of rat2 cells". Mol. Cell. Biol. 17 (6): 3047–55. doi:10.1128/MCB.17.6.3047. PMC 232157. PMID 9154803.
  15. Kimmelman A, Tolkacheva T, Lorenzi MV, Osada M, Chan AM (November 1997). "Identification and characterization of R-ras3: a novel member of the RAS gene family with a non-ubiquitous pattern of tissue distribution". Oncogene. 15 (22): 2675–85. doi:10.1038/sj.onc.1201674. PMID 9400994.
  16. Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line". Blood. 94 (7): 2433–44. doi:10.1182/blood.V94.7.2433.419k31_2433_2444. PMID 10498616. S2CID 40024826.
  17. Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (March 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". J. Biol. Chem. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading

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