RAP2A

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.[5] RAP2A is a member of the Ras-related protein family.

RAP2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesRAP2A, K-REV, KREV, RAP2, RbBP-30, member of RAS oncogene family
External IDsOMIM: 179540 MGI: 97855 HomoloGene: 10875 GeneCards: RAP2A
Orthologs
SpeciesHumanMouse
Entrez

5911

76108

Ensembl

ENSG00000125249

ENSMUSG00000051615

UniProt

P10114

Q80ZJ1

RefSeq (mRNA)

NM_021033

NM_029519

RefSeq (protein)

NP_066361

NP_083795

Location (UCSC)Chr 13: 97.43 – 97.47 MbChr 14: 120.72 – 120.74 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interactions

RAP2A has been shown to interact with RUNDC3A,[6] RASSF5[7] and RALGDS.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000125249 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000051615 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
  6. Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
  7. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
  8. Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading


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