RhoH

RhoH (Ras homolog gene family, member H) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member of the Rac subfamily of the family Rho family of GTPases.[5] It is encoded by the gene RHOH.[6]

RHOH
Identifiers
AliasesRHOH, ARHH, TTF, RhoH, ras homolog family member H
External IDsOMIM: 602037 MGI: 1921984 HomoloGene: 3180 GeneCards: RHOH
Orthologs
SpeciesHumanMouse
Entrez

399

74734

Ensembl

ENSG00000168421

ENSMUSG00000029204

UniProt

Q15669

Q9D3G9

RefSeq (mRNA)

NM_001081105
NM_001363454

RefSeq (protein)

NP_001074574
NP_001350383

Location (UCSC)Chr 4: 40.19 – 40.25 MbChr 5: 66.02 – 66.05 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene

Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. Unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells.[6]

Interactions

RhoH has been shown to interact with ARHGDIA.[7][8]

References

  1. GRCh38: Ensembl release 89: ENSG00000168421 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029204 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ridley AJ (October 2006). "Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking". Trends in Cell Biology. 16 (10): 522–9. doi:10.1016/j.tcb.2006.08.006. PMID 16949823.
  6. "Entrez Gene: RHOH ras homolog gene family, member H".
  7. Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function". Molecular and Cellular Biology. 22 (4): 1158–71. doi:10.1128/MCB.22.4.1158-1171.2002. PMC 134637. PMID 11809807.
  8. Fauré J, Dagher MC (May 2001). "Interactions between Rho GTPases and Rho GDP dissociation inhibitor (Rho-GDI)". Biochimie. 83 (5): 409–14. doi:10.1016/S0300-9084(01)01263-9. PMID 11368848.

Further reading


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