POLR2B

DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the POLR2B gene.[5][6]

POLR2B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPOLR2B, POL2RB, RPB2, hRPB140, hsRPB2, polymerase (RNA) II subunit B, RNA polymerase II subunit B
External IDsOMIM: 180661 MGI: 2388280 HomoloGene: 722 GeneCards: POLR2B
Orthologs
SpeciesHumanMouse
Entrez

5431

231329

Ensembl

ENSG00000047315

ENSMUSG00000029250

UniProt

P30876

Q8CFI7

RefSeq (mRNA)

NM_001303269
NM_000938
NM_001303268

NM_153798

RefSeq (protein)

NP_000929
NP_001290197
NP_001290198

NP_722493

Location (UCSC)Chr 4: 56.98 – 57.03 MbChr 5: 77.46 – 77.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with at least two other polymerase subunits, forms a structure within the polymerase that maintains contact in the active site of the enzyme between the DNA template and the newly synthesized RNA.[7]

Interactions

POLR2B has been shown to interact with POLR2C,[8] POLR2E,[8] POLR2H[8] and POLR2L.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000047315 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000029250 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Acker J, Wintzerith M, Vigneron M, Kedinger C (October 1992). "Primary structure of the second largest subunit of human RNA polymerase II (or B)". J Mol Biol. 226 (4): 1295–9. doi:10.1016/0022-2836(92)91071-V. PMID 1518060.
  6. Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (August 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
  7. "Entrez Gene: POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa".
  8. Acker, J; de Graaff M; Cheynel I; Khazak V; Kedinger C; Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. UNITED STATES. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. ISSN 0021-9258. PMID 9201987.

Further reading

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