SF3B14

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene.[5]

SF3B6
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSF3B6, HSPC175, Ht006, P14, SAP14, SAP14a, SF3B14, SF3B14a, CGI-110, splicing factor 3b subunit 6
External IDsOMIM: 607835 MGI: 1913305 HomoloGene: 9360 GeneCards: SF3B6
Orthologs
SpeciesHumanMouse
Entrez

51639

66055

Ensembl

ENSG00000115128

ENSMUSG00000037361

UniProt

Q9Y3B4

P59708

RefSeq (mRNA)

NM_016047

NM_025323

RefSeq (protein)

NP_057131

NP_079599

Location (UCSC)Chr 2: 24.07 – 24.08 MbChr 12: 4.87 – 4.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site.[5]

Interactions

SF3B14 has been shown to interact with SF3B1.[6][7]

References

  1. GRCh38: Ensembl release 89: ENSG00000115128 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000037361 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SF3B14 splicing factor 3B, 14 kDa subunit".
  6. Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, Lührmann R, Query CC (August 2001). "A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site". EMBO J. 20 (16): 4536–46. doi:10.1093/emboj/20.16.4536. PMC 125580. PMID 11500380.
  7. Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, Lührmann R (September 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937.

Further reading


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