SNX1

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[5] SNX1 is a component of the retromer complex.[6][7]

SNX1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNX1, HsT17379, VPS5, sorting nexin 1
External IDsOMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1
Orthologs
SpeciesHumanMouse
Entrez

6642

56440

Ensembl

ENSG00000028528

ENSMUSG00000032382

UniProt

Q13596

Q9WV80

RefSeq (mRNA)

NM_001242933
NM_003099
NM_148955
NM_152826

NM_019727

RefSeq (protein)

NP_001229862
NP_003090
NP_683758

NP_062701

Location (UCSC)Chr 15: 64.09 – 64.15 MbChr 9: 66 – 66.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[8]

References

  1. GRCh38: Ensembl release 89: ENSG00000028528 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000032382 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. Bibcode:1996Sci...272.1008K. doi:10.1126/science.272.5264.1008. PMID 8638121. S2CID 42608043.
  6. Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. pp. 153–98. doi:10.1016/S1937-6448(08)01204-5. ISBN 9780123747280. PMID 19081543. {{cite book}}: |journal= ignored (help)
  7. Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC 2833274. PMID 18472259.
  8. "Entrez Gene: sorting nexin 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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