SOCS2

Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene.[5][6][7]

SOCS2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSOCS2, CIS2, Cish2, SOCS-2, SSI-2, SSI2, STATI2, suppressor of cytokine signaling 2
External IDsOMIM: 605117 MGI: 1201787 HomoloGene: 2880 GeneCards: SOCS2
Orthologs
SpeciesHumanMouse
Entrez

8835

216233

Ensembl

ENSG00000120833

ENSMUSG00000020027

UniProt

O14508

O35717

RefSeq (mRNA)

NM_001168655
NM_001168656
NM_001168657
NM_007706

RefSeq (protein)

NP_001162126
NP_001162127
NP_001162128
NP_031732

Location (UCSC)Chr 12: 93.57 – 93.58 MbChr 10: 95.22 – 95.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling.[8] Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.[7][9]

Interactions

SOCS2 has been shown to interact with insulin-like growth factor 1 receptor[8] and erythropoietin receptor.[10] Additionally, it acts as a substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex.[11] It is under investigation for use in targeted protein degradation.[12]

References

  1. GRCh38: Ensembl release 89: ENSG00000120833 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020027 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Masuhara M, Sakamoto H, Matsumoto A, Suzuki R, Yasukawa H, Mitsui K, et al. (October 1997). "Cloning and characterization of novel CIS family genes". Biochemical and Biophysical Research Communications. 239 (2): 439–446. doi:10.1006/bbrc.1997.7484. PMID 9344848.
  6. Minamoto S, Ikegame K, Ueno K, Narazaki M, Naka T, Yamamoto H, et al. (August 1997). "Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3". Biochemical and Biophysical Research Communications. 237 (1): 79–83. doi:10.1006/bbrc.1997.7080. PMID 9266833.
  7. "Entrez Gene: SOCS2 suppressor of cytokine signaling 2".
  8. Dey BR, Spence SL, Nissley P, Furlanetto RW (September 1998). "Interaction of human suppressor of cytokine signaling (SOCS)-2 with the insulin-like growth factor-I receptor". The Journal of Biological Chemistry. 273 (37): 24095–24101. doi:10.1074/jbc.273.37.24095. PMID 9727029.
  9. Greenhalgh CJ, Bertolino P, Asa SL, Metcalf D, Corbin JE, Adams TE, et al. (June 2002). "Growth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)". Molecular Endocrinology. 16 (6): 1394–1406. doi:10.1210/mend.16.6.0845. PMID 12040024.
  10. Eyckerman S, Verhee A, der Heyden JV, Lemmens I, Ostade XV, Vandekerckhove J, Tavernier J (December 2001). "Design and application of a cytokine-receptor-based interaction trap". Nature Cell Biology. 3 (12): 1114–1119. doi:10.1038/ncb1201-1114. PMID 11781573. S2CID 10228882.
  11. Kung WW, Ramachandran S, Makukhin N, Bruno E, Ciulli A (June 2019). "Structural insights into substrate recognition by the SOCS2 E3 ubiquitin ligase". Nature Communications. 10 (1): 2534. Bibcode:2019NatCo..10.2534K. doi:10.1038/s41467-019-10190-4. PMC 6557900. PMID 31182716.
  12. Ramachandran S, Makukhin N, Haubrich K, Nagala M, Forrester B, Lynch D, et al. (2022-10-18). "Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2". Nature Communications. 14: 6345. doi:10.1038/s41467-023-41894-3.

Further reading

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