SUZ12

Polycomb protein SUZ12 is a protein that in humans is encoded by the SUZ12 gene.[5][6][7][8]

SUZ12
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSUZ12, CHET9, JJAZ1, SUZ12 polycomb repressive complex 2 subunit, polycomb repressive complex 2 subunit, IMMAS
External IDsOMIM: 606245 MGI: 1261758 HomoloGene: 32256 GeneCards: SUZ12
Orthologs
SpeciesHumanMouse
Entrez

23512

52615

Ensembl

ENSG00000178691

ENSMUSG00000017548

UniProt

Q15022

Q80U70

RefSeq (mRNA)

NM_015355
NM_001321207

NM_001163018
NM_199196

RefSeq (protein)

NP_001308136
NP_056170

NP_001156490
NP_954666

Location (UCSC)Chr 17: 31.94 – 32 MbChr 11: 79.88 – 79.92 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. The specific function of this gene has not yet been determined.[8]

SUZ12, as part of Polycomb Repressive Complex 2 (PRC2), may be involved with chromatin silencing in conjunction with HOTAIR ncRNA, using its zinc-finger domain to bind the RNA molecule.[9]

References

  1. GRCh38: Ensembl release 89: ENSG00000178691 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000017548 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
  6. Koontz JI, Soreng AL, Nucci M, Kuo FC, Pauwels P, van Den Berghe H, Dal Cin P, Fletcher JA, Sklar J (May 2001). "Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6348–53. Bibcode:2001PNAS...98.6348K. doi:10.1073/pnas.101132598. PMC 33471. PMID 11371647.
  7. Ross PJ, Ragina NP, Rodriguez RM, Iager AE, Siripattarapravat K, Lopez-Corrales N, Cibelli JB (December 2008). "Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development". Reproduction. 136 (6): 777–85. doi:10.1530/REP-08-0045. PMID 18784248.
  8. "Entrez Gene: SUZ12 suppressor of zeste 12 homolog (Drosophila)".
  9. Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY (June 2007). "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell. 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720.

Further reading

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