SYNJ2

Synaptojanin 2 is a protein that in humans is encoded by the SYNJ2 gene.[5]

SYNJ2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSYNJ2, INPP5H, synaptojanin 2
External IDsOMIM: 609410 MGI: 1201671 HomoloGene: 117703 GeneCards: SYNJ2
Orthologs
SpeciesHumanMouse
Entrez

8871

20975

Ensembl

ENSG00000078269

ENSMUSG00000023805

UniProt

O15056

Q9D2G5

RefSeq (mRNA)

NM_001178088
NM_003898

RefSeq (protein)

NP_001171559
NP_003889

Location (UCSC)Chr 6: 157.98 – 158.1 MbChr 17: 5.99 – 6.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

The gene is a member of the inositol-polyphosphate 5-phosphatase family. The encoded protein interacts with the ras-related C3 botulinum toxin substrate 1, which causes translocation of the encoded protein to the plasma membrane where it inhibits clathrin-mediated endocytosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].

References

  1. GRCh38: Ensembl release 89: ENSG00000078269 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000023805 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: Synaptojanin 2".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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