Inositol-polyphosphate 5-phosphatase

The enzyme Inositol-polyphosphate 5-phosphatase (EC 3.1.3.56, systematic name 1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase; other names type I inositol-polyphosphate phosphatase, inositol trisphosphate phosphomonoesterase, InsP3/Ins(1,3,4,5)P4 5-phosphatase, inosine triphosphatase, D-myo-inositol 1,4,5-triphosphate 5-phosphatase, D-myo-inositol 1,4,5-trisphosphate 5-phosphatase, L-myo-inositol 1,4,5-trisphosphate-monoesterase, inositol phosphate 5-phosphomonoesterase, inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase, Ins(1,4,5)P3 5-phosphataseD-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase, inositol 1,4,5-trisphosphate phosphatase, inositol polyphosphate-5-phosphatase, myo-inositol-1,4,5-trisphosphate 5-phosphatase, inositol-1,4,5-trisphosphate 5-phosphatase)[1][2][3][4] catalyses the following reaction

(1) D-myo-inositol 1,4,5-trisphosphate + H2O myo-inositol 1,4-bisphosphate + phosphate
(2) 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O 1D-myo-inositol 1,3,4-trisphosphate + phosphate
Inositol-polyphosphate 5-phosphatase
Identifiers
EC no.3.1.3.56
CAS no.106283-14-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

Ten mammalian isoforms are known.[5]

References
  1. Downes CP, Mussat MC, Michell RH (April 1982). "The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane". The Biochemical Journal. 203 (1): 169–77. doi:10.1042/bj2030169. PMC 1158207. PMID 6285891.
  2. Erneux C, Lemos M, Verjans B, Vanderhaeghen P, Delvaux A, Dumont JE (May 1989). "Soluble and particulate Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase in bovine brain". European Journal of Biochemistry. 181 (2): 317–22. doi:10.1111/j.1432-1033.1989.tb14726.x. PMID 2540972.
  3. Woscholski, R.; Parker, P.J. (2000). "Inositol phosphatases: constructive destruction of phosphoinositides and inositol phosphates". In Cockcroft, S. (ed.). Biology of Phosphoinositides. Oxford: Biology of Phosphoinositides. pp. 320–338.
  4. Verjans B, De Smedt F, Lecocq R, Vanweyenberg V, Moreau C, Erneux C (May 1994). "Cloning and expression in Escherichia coli of a dog thyroid cDNA encoding a novel inositol 1,4,5-trisphosphate 5-phosphatase". The Biochemical Journal. 300 ( Pt 1): 85–90. doi:10.1042/bj3000085. PMC 1138127. PMID 8198557.
  5. Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA (2009). "The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease". The Biochemical Journal. 419 ( Pt 1): 29–49. doi:10.1042/BJ20081673. PMID 19272022.
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