Scyllo-inosamine 4-kinase

In enzymology, a scyllo-inosamine 4-kinase (EC 2.7.1.65) is an enzyme that catalyzes the chemical reaction

ATP + 1-amino-1-deoxy-scyllo-inositol ADP + 1-amino-1-deoxy-scyllo-inositol 4-phosphate
scyllo-inosamine 4-kinase
Identifiers
EC no.2.7.1.65
CAS no.37278-08-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
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NCBIproteins

Thus, the two substrates of this enzyme are ATP and 1-amino-1-deoxy-scyllo-inositol, whereas its two products are ADP and 1-amino-1-deoxy-scyllo-inositol 4-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-amino-1-deoxy-scyllo-inositol 4-phosphotransferase. Other names in common use include scyllo-inosamine kinase (phosphorylating), scyllo-inosamine kinase, and ATP:inosamine phosphotransferase. This enzyme participates in streptomycin biosynthesis.

References

    • Walker JB (1971). "Enzymatic reactions involved in streptomycin biosynthesis and metabolism". Lloydia. 34 (4): 363–71. PMID 4376579.
    • Walker JB, Walker MS (1967). "Enzymatic synthesis of streptidine from scyllo-inosamine". Biochemistry. 6 (12): 3821–9. doi:10.1021/bi00864a028. PMID 6076630.


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