SEMA4D

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.[5]

SEMA4D
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSEMA4D, C9orf164, CD100, M-sema-G, SEMAJ, coll-4, semaphorin 4D, COLL4, A8, GR3, BB18
External IDsOMIM: 601866 MGI: 109244 HomoloGene: 21282 GeneCards: SEMA4D
Orthologs
SpeciesHumanMouse
Entrez

10507

20354

Ensembl

ENSG00000187764

ENSMUSG00000021451

UniProt

Q92854

O09126

RefSeq (mRNA)

NM_001281880
NM_013660

RefSeq (protein)
Location (UCSC)Chr 9: 89.36 – 89.5 MbChr 13: 51.69 – 51.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function

Semaphorin 4D (Sema 4D) is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.[6]

In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still under investigation.[7][8]

During skin damage repairs, SEMA4D interacts with Plexin B2 on Gamma delta T cells to play a role in the healing process.[9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000187764 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000021451 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D".
  6. Ito Y, Oinuma I, Katoh H, Kaibuchi K, Negishi M (July 2006). "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports. 7 (7): 704–9. doi:10.1038/sj.embor.7400737. PMC 1500830. PMID 16799460.
  7. Kumanogoh A, Watanabe C, Lee I, Wang X, Shi W, Araki H, Hirata H, Iwahori K, Uchida J, Yasui T, Matsumoto M, Yoshida K, Yakura H, Pan C, Parnes JR, Kikutani H (November 2000). "Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling". Immunity. 13 (5): 621–31. doi:10.1016/S1074-7613(00)00062-5. PMID 11114375.
  8. Ishida I, Kumanogoh A, Suzuki K, Akahani S, Noda K, Kikutani H (August 2003). "Involvement of CD100, a lymphocyte semaphorin, in the activation of the human immune system via CD72: implications for the regulation of immune and inflammatory responses". Int. Immunol. 15 (8): 1027–34. doi:10.1093/intimm/dxg098. PMID 12882840.
  9. Deborah A. Witherden; Megumi Watanabe; Olivia Garijo; Stephanie E. Rieder; Gor Sarkisyan; Shane J.F. Cronin; Petra Verdino; Ian A. Wilson; Atsushi Kumanogoh; Hitoshi Kikutani; Luc Teyton; Wolfgang H. Fischer; Wendy L. Havran (August 2012). "The CD100 Receptor Interacts with Its Plexin B2 Ligand to Regulate Epidermal γδ T Cell Function". Immunity. 37 (2): 314–25. doi:10.1016/j.immuni.2012.05.026. PMC 3430606. PMID 22902232.

Further reading


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