Small nucleolar RNA TBR2

Small nucleolar RNA TBR2 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

snoTBR2
Predicted secondary structure and sequence conservation of Small nucleolar RNA TBR2
Identifiers
Rfam	RF02786
Other data
Domain(s)	Eukaryota
GO	GO:0006396 ,GO:0005730
SO	SO:0000593
PDB structures	PDBe

snoRNA TBR2 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family direct site-specific 2'-O-methylation of substrate RNAs.[1]

TBR2 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies.[2] Together with TBR12, TBR6 and TBR4 it is a part of snoRNA gene cluster that is tandemly repeated. These 4 snoRNA genes are transcribed as a polycistronic RNA transcript.[3]