Small nucleolar RNA TBR7

In molecular biology, Small nucleolar RNA TBR7 is a non-coding RNA (ncRNA) molecule identified in Trypanosoma brucei which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA TBR7
Predicted secondary structure and sequence conservation of snoTBR7
Identifiers
SymbolsnoTBR7
RfamRF00295
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA TBR7 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

TBR7 was one of seventeen snoRNAs identified in Trypanosoma brucei by immunoprecipitation with anti-fibrillarin antibodies.[2] It is predicted to guide the 2'O ribosome methylation of 18s ribosomal RNA (rRNA).

Together with TBR5 and TBR17 it is a part of a tandemly repeated snoRNA gene cluster, located within the spliced leader RNA (SLA).[3] The cluster genes are produced as polycistronic RNA.[4]

See also

Small nucleolar RNA TBR2

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Dunbar DA, Wormsley S, Lowe TM, Baserga SJ (2000). "Fibrillarin-associated box C/D small nucleolar RNAs in Trypanosoma brucei. Sequence conservation and implications for 2'-O-ribose methylation of rRNA". J. Biol. Chem. 275 (19): 14767–76. doi:10.1074/jbc.M001180200. PMID 10747997.
  3. Roberts, T. G.; Sturm, N. R.; Yee, B. K.; Yu, M. C.; Hartshorne, T.; Agabian, N.; Campbell, D. A. (August 1998). "Three small nucleolar RNAs identified from the spliced leader-associated RNA locus in kinetoplastid protozoans". Molecular and Cellular Biology. 18 (8): 4409–4417. doi:10.1128/mcb.18.8.4409. ISSN 0270-7306. PMC 109026. PMID 9671450.
  4. Dunbar, D. A.; Chen, A. A.; Wormsley, S.; Baserga, S. J. (2000-08-01). "The genes for small nucleolar RNAs in Trypanosoma brucei are organized in clusters and are transcribed as a polycistronic RNA". Nucleic Acids Research. 28 (15): 2855–2861. doi:10.1093/nar/28.15.2855. ISSN 1362-4962. PMC 102681. PMID 10908346.


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