Small nucleolar RNA R32/R81/Z41

In molecular biology, Small nucleolar RNA Z41 (homologous to R32 and R81) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Z41 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2] Plant snoRNA Z41 was identified in screens of Arabidopsis thaliana.[3][4]

Small nucleolar RNA R32/R81/Z41
Predicted secondary structure and sequence conservation of snoR32_R81
Identifiers
SymbolsnoR32_R81
RfamRF00356
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
  3. Barneche F, Gaspin C, Guyot R, Echeverría M (2001). "Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites". J. Mol. Biol. 311 (1): 57–73. doi:10.1006/jmbi.2001.4851. PMID 11469857.
  4. Qu LH, Meng Q, Zhou H, et al. (2001). "Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana". Nucleic Acids Res. 29 (7): 1623–30. doi:10.1093/nar/29.7.1623. PMC 31268. PMID 11266566.


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