Small nucleolar RNA SNORA48
In molecular biology, Small nucleolar RNA SNORA48 is a pseudouridylation guide H/ACA box snoRNA. This snoRNA was cloned in 2004[1] from a HeLa cell extract immunoprecipitated with an anti-GAR1 antibody. It is predicted to guide the pseudouridylation of residue U3797 of 28S rRNA.
| Small nucleolar RNA SNORA48 | |
|---|---|
 Predicted secondary structure and sequence conservation of SNORA48 | |
| Identifiers | |
| Symbol | SNORA48 |
| Alt. Symbols | snoACA48 |
| Rfam | RF00554 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; H/ACA-box |
| Domain(s) | Eukaryota |
| GO | GO:0006396 GO:0005730 |
| SO | SO:0000594 |
| PDB structures | PDBe |
The pseudouridylation of this residue had been reported in 1997.[2] The H/ACA box snoRNAs ACA48 and U67, and the C/D box snoRNA mgU6-77, share the same host gene (EIF4A1).
References
- Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
- Ofengand J, Bakin A (February 1997). "Mapping to nucleotide resolution of pseudouridine residues in large subunit ribosomal RNAs from representative eukaryotes, prokaryotes, archaebacteria, mitochondria and chloroplasts". Journal of Molecular Biology. 266 (2): 246–68. doi:10.1006/jmbi.1996.0737. PMID 9047361.
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