Small nucleolar RNA SNORD73

In molecular biology, snoRNA U73 (also known as SNORD73) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD73
Predicted secondary structure and sequence conservation of SNORD73
Identifiers
SymbolSNORD73
Alt. SymbolsU73
RfamRF00071
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA U73 is a member of the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U73 is encoded within the introns of ribosomal protein S3a and contains a 12 nucleotide region of complementarity to a conserved sequence in 28S ribosomal RNA (rRNA).[2] U73 has been demonstrated to function as a 2'-O-ribose methylation guide RNA for pre-28S rRNA.[3]

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Rebane A, Tamme R, Laan M, Pata I, Metspalu A (April 1998). "A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes". Gene. 210 (2): 255–63. doi:10.1016/S0378-1119(98)00070-5. PMID 9573378.
  3. Rebane A, Roomere H, Metspalu A (2002). "Locations of several novel 2'-O-methylated nucleotides in human 28S rRNA". BMC Molecular Biology. 3: 1. doi:10.1186/1471-2199-3-1. PMC 88882. PMID 11897011.
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