Small nucleolar RNA SNORA77

In molecular biology, Small nucleolar RNA SNORA77 (also known as ACA63) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA).

Small nucleolar RNA SNORA77
Predicted secondary structure and sequence conservation of SNORA77
Identifiers
SymbolSNORA77
RfamRF00599
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

SNORA77 was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis.[1] It belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure and conserved H/ACA-box motifs.[2]

SNORA77 is proposed to guide the pseudouridylation of 18S ribosomal RNA (rRNA) residue U814.[3] Pseudouridylation is the isomerisation of the nucleoside uridine to the different isomeric form pseudouridine.

References
  1. Schattner P, Barberan-Soler S, Lowe TM (January 2006). "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA. 12 (1): 15–25. doi:10.1261/rna.2210406. PMC 1370881. PMID 16373490.
  2. Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–5807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  3. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158–162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
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