Small nucleolar RNA Me28S-Am2634

In molecular biology, Small nucleolar RNA Me28S-Am2634 (also known as snoRNA Me28S-Am2634) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis of other small nuclear RNAs (snRNAs). Small nucleolar RNAs (snoRNAs) are modifying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

Small nucleolar RNA Me28S-Am2634
Predicted secondary structure and sequence conservation of snoMe28S-Am2634
Identifiers
SymbolsnoMe28S-Am2634
RfamRF00537
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA Me28S-Am2634 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] It is predicted to guide the 2'-O-methylation of 28S ribosomal RNA (rRNA) residue A-2634.[2]

This snoRNA has currently only been identified in the fly species Drosophila melanogaster.

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Huang ZP, Zhou H, He HL, Chen CL, Liang D, Qu LH (2005). "Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs". RNA. 11 (8): 1303–16. doi:10.1261/rna.2380905. PMC 1370813. PMID 15987805.


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