Small nucleolar RNA SNORA70

In molecular biology, Small nucleolar RNA SNORA70 (also known as U70) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

Small nucleolar RNA SNORA70
Predicted secondary structure and sequence conservation of SNORA70
Identifiers
SymbolSNORA70
Alt. SymbolsU70
RfamRF00156
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

ACA70 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA70 is predicted to guide the pseudouridylation of U1692 of 18S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

References
  1. Ganot P, Caizergues-Ferrer M, Kiss T (April 1997). "The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation". Genes & Development. 11 (7): 941–56. doi:10.1101/gad.11.7.941. PMID 9106664.
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