Small nucleolar RNA SNORD43

In molecular biology, snoRNA U43 (also known as SNORD43) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD43
Predicted secondary structure and sequence conservation of SNORD43
Identifiers
SymbolSNORD43
Alt. SymbolsU43
RfamRF00221
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA U43 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U43 is encoded in intron 1 of the ribosomal protein L3 gene in human and cow.[2] Three other snoRNAs ( U82, U83a and U83b) are also encoded in the same host gene but from different introns.[2] The Arabidopsis thaliana homologue is called snoR41 in the public sequence databases (Genbank). The rice homologue is expressed from a cluster also containing snoR16.[3]

U43 is hypothesised to guide methylation of 2'-O-ribose residues on 18S ribosomal RNA.[3]

References
  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Duga S, Asselta R, Malcovati M, Tenchini ML, Ronchi S, Simonic T (February 2000). "The intron-containing L3 ribosomal protein gene (RPL3): sequence analysis and identification of U43 and of two novel intronic small nucleolar RNAs". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1490 (3): 225–36. doi:10.1016/S0167-4781(99)00237-7. PMID 10684968.
  3. Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (May 2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Research. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC 156054. PMID 12736310.
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