Small nucleolar RNA SNORA58

In molecular biology, Small nucleolar RNA SNORA58 (also known as ACA58) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a "guide RNA".

Small nucleolar RNA SNORA58
Predicted secondary structure and sequence conservation of SNORA58
Identifiers
SymbolSNORA58
Alt. SymbolssnoACA58
RfamRF00418
Other data
RNA typeGene; snRNA; snoRNA; H/ACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000594
PDB structuresPDBe

ACA58 was originally cloned from HeLa cells[1] and belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein. snoRNA ACA58 is predicted to guide the pseudouridylation of U3823 of 28S ribosomal RNA (rRNA). Pseudouridylation is the (isomerisation of the nucleoside uridine) to the different isomeric form pseudouridine.

snoRNA ACA58 is homologous to the mouse snoRNA sequence MBI-12 described in.[2]

References
  1. Kiss AM, Jády BE, Bertrand E, Kiss T (July 2004). "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology. 24 (13): 5797–807. doi:10.1128/MCB.24.13.5797-5807.2004. PMC 480876. PMID 15199136.
  2. Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J (June 2001). "RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse". The EMBO Journal. 20 (11): 2943–53. doi:10.1093/emboj/20.11.2943. PMC 125495. PMID 11387227.
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