Small nucleolar RNA SNORD24

In molecular biology, U24 is a member of the C/D class of snoRNA which contain the C (UGAUGA) and D (CUGA) box motifs.[1] C/D box snoRNAs have been shown to act as methylation guides for a number of RNA targets.[2][3] U24 is encoded within an intron of the gene for ribosomal protein L7a in mammals, chicken and Fugu.[4] The U76/SNORD76 snoRNA is found in an intron of the uRNA host gene (UHG) growth arrest specific 5 (GAS5) transcript gene.[5] snoRNAs Z20 and U76 snoRNAs show clear similarity to U24.

Small nucleolar RNA SNORD24
Predicted secondary structure and sequence conservation of SNORD24
Identifiers
SymbolSNORD24
Alt. SymbolsU24
RfamRF00069
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

An experiment that looked at 22 different non-small-cell lung cancer tissues found that SNORD33, SNORD66 and SNORD76 were over-expressed relative to matched noncancerous lung tissues.[6]

References
  1. Qu LH, Henry Y, Nicoloso M, Michot B, Azum MC, Renalier MH, Caizergues-Ferrer M, Bachellerie JP (July 1995). "U24, a novel intron-encoded small nucleolar RNA with two 12 nt long, phylogenetically conserved complementarities to 28S rRNA". Nucleic Acids Research. 23 (14): 2669–76. doi:10.1093/nar/23.14.2669. PMC 307091. PMID 7651828.
  2. Nicoloso M, Qu LH, Michot B, Bachellerie JP (July 1996). "Intron-encoded, antisense small nucleolar RNAs: the characterization of nine novel species points to their direct role as guides for the 2'-O-ribose methylation of rRNAs". Journal of Molecular Biology. 260 (2): 178–95. doi:10.1006/jmbi.1996.0391. PMID 8764399.
  3. Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114. S2CID 10418885.
  4. Gilley J, Fried M (July 1998). "Evolution of U24 and U36 snoRNAs encoded within introns of vertebrate rpL7a gene homologs: unique features of mammalian U36 variants". DNA and Cell Biology. 17 (7): 591–602. doi:10.1089/dna.1998.17.591. PMID 9703018.
  5. Hirose T, Steitz JA (November 2001). "Position within the host intron is critical for efficient processing of box C/D snoRNAs in mammalian cells". Proceedings of the National Academy of Sciences of the United States of America. 98 (23): 12914–9. Bibcode:2001PNAS...9812914H. doi:10.1073/pnas.231490998. JSTOR 3057015. PMC 60799. PMID 11606788.
  6. Liao J, Yu L, Mei Y, Guarnera M, Shen J, Li R, Liu Z, Jiang F (July 2010). "Small nucleolar RNA signatures as biomarkers for non-small-cell lung cancer". Molecular Cancer. 9: 198. doi:10.1186/1476-4598-9-198. PMC 2919450. PMID 20663213.
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