Small nucleolar RNA snR69

In molecular biology, snoRNA snR69 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR69 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA snR69 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.[2]

Small nucleolar RNA snR69
Predicted secondary structure and sequence conservation of snosnR69
Identifiers
Symbol	snosnR69
Rfam	RF00475
Other data
RNA type	Gene; snRNA; snoRNA; CD-box
Domain(s)	Eukaryota
GO	GO:0005730 GO:0006396
SO	SO:0000593
PDB structures	PDBe