Small nucleolar RNA SNORD56

In molecular biology, snoRNA U56 (also known as SNORD56) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD56
Identifiers
SymbolSNORD56
Alt. SymbolsU56
RfamRF00275
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

snoRNA U56 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

U56 was originally cloned from HeLa cells and is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue C517.[2][3] In the human genome U56 is encoded in the introns of the same host gene as several other snoRNAs (C/D box snoRNAs U57, U86 and HBII-55, and the H/ACA box snoRNA ACA51).[3] This host gene encodes Nucleolar Protein 5A (NOL5A).

References

  1. Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I (October 2002). "Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro". Molecular and Cellular Biology. 22 (19): 6663–8. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (June 1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114. S2CID 10418885.
  3. Lestrade L, Weber MJ (January 2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Database issue): D158-62. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.
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