Small nucleolar RNA R38

In molecular biology, Small nucleolar RNA R38 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA R38 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA R38 has been identified in human, yeast,[2] Arabidopsis thaliana [3] and Oryza sativa .[4] snoRNA R38 guides the methylation of 2'-O-ribose sites in 28S rRNA.

Small nucleolar RNA R38
Predicted secondary structure and sequence conservation of snoR38
Identifiers
SymbolsnoR38
RfamRF00213
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Bachellerie JP, Michot B, Nicoloso M, Balakin A, Ni J, Fournier MJ (1995). "Antisense snoRNAs: a family of nucleolar RNAs with long complementarities to rRNA". Trends Biochem. Sci. 20 (7): 261–4. doi:10.1016/S0968-0004(00)89039-8. PMID 7667877.
  3. Qu LH, Meng Q, Zhou H, et al. (2001). "Identification of 10 novel snoRNA gene clusters from Arabidopsis thaliana". Nucleic Acids Res. 29 (7): 1623–30. doi:10.1093/nar/29.7.1623. PMC 31268. PMID 11266566.
  4. Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH (2003). "The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa". Nucleic Acids Res. 31 (10): 2601–13. doi:10.1093/nar/gkg373. PMC 156054. PMID 12736310.


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