Small nucleolar RNA snoR639/H1

In molecular biology, Small nucleolar RNA snoR639 (also known as snoH1) is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a 'guide RNA'.

Small nucleolar RNA snoR639/H1
Predicted secondary structure and sequence conservation of snoR639
Identifiers
SymbolsnoR639
RfamRF00291
Other data
RNA typeGene; snRNA; snoRNA; HACA-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0001263
PDB structuresPDBe

snoR639 was originally identified in a study of Drosophila melanogaster minifly (mfl) gene; snoR639 resides in the intron of this gene.[1] It was later rediscovered by a large-scale RNomics effort.[2] snoR639 belongs to the H/ACA box class of snoRNAs as it has the predicted hairpin-hinge-hairpin-tail structure, has the conserved H/ACA-box motifs and is found associated with GAR1 protein.

References
  1. Giordano E, Peluso I, Senger S, Furia M (March 1999). "minifly, a Drosophila gene required for ribosome biogenesis". The Journal of Cell Biology. 144 (6): 1123–33. doi:10.1083/jcb.144.6.1123. PMC 2150573. PMID 10087258.
  2. Yuan G, Klämbt C, Bachellerie JP, Brosius J, Hüttenhofer A (May 2003). "RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs". Nucleic Acids Research. 31 (10): 2495–507. doi:10.1093/nar/gkg361. PMC 156043. PMID 12736298.
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