Small nucleolar RNA snR61/Z1/Z11

In molecular biology, Small nucleolar RNA snR61/Z1/Z11 refers to a group of related non-coding RNA (ncRNA) molecules which function in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

Small nucleolar RNA snR61/Z1/Z11
Predicted secondary structure and sequence conservation of snosnR61
Identifiers
SymbolsnosnR61
RfamRF00476
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

These related snoRNAs include yeast (Schizosaccharomyces pombe) snR61, fly (Drosophila melanogaster) Z1 [1] and yeast (Saccharomyces cerevisiae) snR61 and Z11 snoRNAs. They are predicted to belong to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[2]

References
  1. Yuan G, Klämbt C, Bachellerie JP, Brosius J, Hüttenhofer A (2003). "RNomics in Drosophila melanogaster: identification of 66 candidates for novel non-messenger RNAs". Nucleic Acids Res. 31 (10): 2495–507. doi:10.1093/nar/gkg361. PMC 156043. PMID 12736298.
  2. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.


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