Small nucleolar RNA SNORD22

In molecular biology, snoRNA U22 (also known as SNORD22) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD22
Predicted secondary structure and sequence conservation of SNORD22
Identifiers
SymbolSNORD22
Alt. SymbolsU22
RfamRF00099
Other data
RNA typeGene; snRNA; snoRNA; CD-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

U22 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1]

In the human genome snoRNA U22 is encoded along with seven other snoRNAs within the introns of the same gene (called UHG for U22 host gene) in mammals.[2] U22 has also been identified in the amphibian Xenopus laevis[3] U22 is predicted to guide the 2'-O-ribose methylation guide for ribosomal RNA.[3]

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Tycowski KT, Shu MD, Steitz JA (1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. Bibcode:1996Natur.379..464T. doi:10.1038/379464a0. PMID 8559254. S2CID 4319950.
  3. Tycowski KT, Shu MD, Steitz JA (1994). "Requirement for intron-encoded U22 small nucleolar RNA in 18S ribosomal RNA maturation". Science. 266 (5190): 1558–61. Bibcode:1994Sci...266.1558T. doi:10.1126/science.7985025. PMID 7985025.


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