Small nucleolar RNA SNORD29

In molecular biology, SNORD29 (also known as U29) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

Small nucleolar RNA SNORD29
Predicted secondary structure and sequence conservation of SNORD29
Identifiers
SymbolSNORD29
Alt. SymbolsU29
RfamRF00070
Other data
RNA typeGene; snRNA; snoRNA; C/D-box
Domain(s)Eukaryota
GOGO:0006396 GO:0005730
SOSO:0000593
PDB structuresPDBe

U29 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2]

In humans U29 and several other snoRNAs (U22 and U25-U31) are located in the introns of the same gene (called UHG for U22 host gene).[3][4] U29 is proposed to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) residue A4493.[5][6]

References
  1. Galardi, S.; Fatica, A.; Bachi, A.; Scaloni, A.; Presutti, C.; Bozzoni, I. (October 2002). "Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro". Molecular and Cellular Biology. 22 (19): 6663–6668. doi:10.1128/MCB.22.19.6663-6668.2002. PMC 134041. PMID 12215523.
  2. Kiss T (2002). "Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions". Cell. 109 (2): 145–8. doi:10.1016/S0092-8674(02)00718-3. PMID 12007400. S2CID 8968788.
  3. Tycowski KT, Shu MD, Steitz JA (1996). "A mammalian gene with introns instead of exons generating stable RNA products". Nature. 379 (6564): 464–6. Bibcode:1996Natur.379..464T. doi:10.1038/379464a0. PMID 8559254. S2CID 4319950.
  4. Tycowski KT, Smith CM, Shu MD, Steitz JA (1996). "A small nucleolar RNA requirement for site-specific ribose methylation of rRNA in Xenopus". Proc. Natl. Acad. Sci. U.S.A. 93 (25): 14480–5. Bibcode:1996PNAS...9314480T. doi:10.1073/pnas.93.25.14480. PMC 26158. PMID 8962077.
  5. Kiss-László Z, Henry Y, Bachellerie JP, Caizergues-Ferrer M, Kiss T (1996). "Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs". Cell. 85 (7): 1077–88. doi:10.1016/S0092-8674(00)81308-2. PMID 8674114. S2CID 10418885.
  6. Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research. 34 (Supplement 1: Database Issue): D158–D162. CiteSeerX 10.1.1.105.7552. doi:10.1093/nar/gkj002. PMC 1347365. PMID 16381836.


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