Sorbitol-6-phosphate 2-dehydrogenase
In enzymology, a sorbitol-6-phosphate dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction
- D-sorbitol 6-phosphate + NAD+ D-fructose 6-phosphate + NADH + H+
| sorbitol-6-phosphate 2-dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.140 | ||||||||
| CAS no. | 37250-69-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD+, whereas its 3 products are D-fructose 6-phosphate, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.
References
- Du Toit PJ, Kotze JP (1970). "The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum". Biochim. Biophys. Acta. 206 (3): 333–42. doi:10.1016/0005-2744(70)90150-6. PMID 4318899.
- Liss M, Horwitz SB, Kaplan NO (1962). "D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes". J. Biol. Chem. 237: 1342–50. PMID 14465816.