South Carolina Highway 101

SC 101 begins in Hickory Tavern at US 76 and heads northwest. At the intersection of State Road S-30-20, the highway then turns to the northeast and heads toward Gray Court. It intersects SC 14 in downtown and then interchanges with I-385 at exit 16 while it continues northeast. The route then enters Woodruff and runs concurrently with US 221 and SC 146 for about 1 mile (1.6 km). Northwest of Woodruff, the highway then heads west, remaining concurrent with SC 146. It intersects with SC 418 as it exits town. Outside the city limits of Woodruff, SC 101 splits from SC 146 and heads northwest, intersecting SC 417 and SC 296.[4]

Northwest of Reidville, the highway interchanges with I-85 at exit 60, forming a parclo interchange. Continuing into Greer, the highway passes Greenville-Spartanburg International Airport before intersecting SC 80. In Greer, the highway intersects with SC 357's southern terminus and becomes concurrent with SC 290 heading west. It then runs concurrently with US 29 for about 0.3 miles (0.48 km) and then continues northwest. After about a tenth of a mile, SC 101 tracks north, crossing over the South Tyger River before making its way through Highland, and running concurrent with SC 414 for a tenth of a mile before continuing northwest. The route reaches its northern terminus at SC 11 in northern Greenville County.[5]

South Carolina Highway 101 Truck (SC 101 Truck) is a 5.610-mile (9.028 km) truck route that is partially within the city limits of Greer. It has concurrencies with SC 80 and SC 14.

The truck route begins at an intersection with the SC 101 mainline at that highway's intersection with SC 80 (J. Verne Smith Parkway) in the southern part of Greer, which is in the southwestern part of Spartanburg County. This intersection is just north of the Greenville–Spartanburg International Airport. SC 80 and SC 101 Truck travel to the southwest, skirting along the southern edges of the city. They travel through rural portions of the city, just to the west of the airport. Just past an intersection with the southern terminus of Poplar Street Extension, they enter the east-central part of Greenville County. Just before an intersection with the southern terminus of Old Highway 14 South (a former portion of SC 14), they curve to the west and leave the airport area. After a slight bend to the west-southwest, they intersect SC 14 and the eastern terminus of Tandem Drive. Here, SC 80 reaches its western terminus, and SC 101 Truck turns right to follow SC 14 north to the north-northwest. Immediately, they temporarily leave the city limits of Greer. They curve to the northeast and begin a curve back to the north-northwest. At an intersection with the southern terminus of SC 14 Truck (South Buncombe Road), they re-enter the city. This intersection leads to Greenville Technical College's Benson Campus, North Greenville University, and Prisma Health Greer Memorial Hospital. They curve to the northeast and intersect the eastern terminus of West Road and the western terminus of Roscoe Road, where they leave the city limits again. A short distance later, they re-enter the city for the final time. At an intersection with Donaldson Avenue, they begin a curve to the north-northwest. After a slight bend to the north-northeast, they travel on a bridge over some railroad tracks of Norfolk Southern Railway. Then, they cross over some railroad tracks of CSX. Just past the northern terminus of School Street, they pass the Greer Heritage Museum. At Poinsett Street, they intersect SC 101/SC 290. Here, SC 101 Truck ends, and SC 14 continues to the northeast.[9]

The entire route is in Greer.

County	mi[6][7][8]	km	Destinations	Notes
Spartanburg	0.000	0.000	SC 80 east (J. Verne Smith Parkway) / SC 101 (New Woodruff Road) – Greer, SC Inland Port Terminal	Southern end of SC 80 concurrency; southern terminus
Greenville	1.770	2.849	Old Highway 14 South north	Southern terminus of Old Highway 14 South; former SC 14 north
	2.120	3.412	SC 14 south / Tandem Drive west – Simpsonville	Northern end of SC 80 concurrency; southern end of SC 14 concurrency; eastern terminus of Tandem Drive
	3.580	5.761	South Buncombe Road (SC 14 Truck north) – Greenville Tech Benson Campus, North Greenville University	Southern terminus of SC 14 Truck; provides access to Prisma Health Greer Memorial Hospital
	5.610	9.028	SC 101 / SC 290 (Poinsett Street) / SC 14 north (North Main Street) – City stadium, Chamber of commerce	Northern end of SC 14 concurrency; northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

•  U.S. roads portal

• Media related to South Carolina Highway 101 at Wikimedia Commons
• SC 101 at Virginia Highways' South Carolina Highways Annex