Streptomycin 3"-kinase

In enzymology, a streptomycin 3"-kinase (EC 2.7.1.87) is an enzyme that catalyzes the chemical reaction

ATP + streptomycin ADP + streptomycin 3"-phosphate
streptomycin 3"-kinase
Identifiers
EC no.2.7.1.87
CAS no.39391-15-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

Thus, the two substrates of this enzyme are ATP and streptomycin, whereas its two products are ADP and streptomycin 3''-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:streptomycin 3"-phosphotransferase. Other names in common use include streptomycin 3"-kinase (phosphorylating), and streptomycin 3"-phosphotransferase.

References

    • Walker JB, Skorvaga M (1973). "Phosphorylation of streptomycin and dihydrostreptomycin by Streptomyces. Enzymatic synthesis of different diphosphorylated derivatives". J. Biol. Chem. 248 (7): 2435–40. PMID 4121456.


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