Sylvie Garneau-Tsodikova

Sylvie Garneau-Tsodikova is a French Canadian chemist who is a Professor and Associate Vice President for Research at the University of Kentucky. Her research considers the development of new molecules that can combat bacterial resistance.

Sylvie Garneau-Tsodikova
Alma materUniversité Laval
University of Alberta
Scientific career
InstitutionsHarvard Medical School
University of Michigan
University of Kentucky
ThesisNew antimicrobial agents acting on bacterial cell walls. (2003)

Early life and education

Garneau-Tsodikova was born in Quebec City, Canada. She attended the Université Laval for her undergraduate studies in chemistry, where she graduated top of the class.[1] As a student, she was honoured with several awards, including distinguishments from the Chemical Institute of Canada and Natural Sciences and Engineering Research Council.[1] She completed a Master's thesis on the synthesis of glutamyl transfer RNA synthetase inhibitors.[2] She moved to the University of Alberta for graduate studies, where she worked on the impact of antimicrobial agents of bacterial cell walls.[3][4] During her doctoral studies she became interested in infectious diseases and the development of antibacterial agents.[5]

Research and career

Garneau-Tsodikova moved to the Harvard Medical School for her postdoctoral training where she worked with Christopher T. Walsh on the formation and modification of dipyrroles. At Harvard she was trained in both enzymology and biochemistry. In 2006, Garneau-Tsodikova moved to the University of Michigan, where she was made Assistant Professor in the College of Pharmacy.[6] She spent seven years at Michigan, until she moved to the University of Kentucky. She was promoted to Professor and Assistant Dean in 2018.[7]

Garneau-Tsodikova's research focuses on the development of antifungal and antibacterial agents.[5] In particular, Garneau-Tsodikova studied tuberculosis and Candida auris resistant pathogens.[5] She was involved with the development of multifunctional enzymes with tuneable biological properties. She is an Associate Editor of the Royal Society of Chemistry journal Medicinal Chemistry.[8]

Selected publications
  • Christopher T Walsh; Sylvie Garneau-Tsodikova; Gregory J Gatto (1 December 2005). "Protein posttranslational modifications: the chemistry of proteome diversifications". Angewandte Chemie International Edition. 44 (45): 7342–7372. doi:10.1002/ANIE.200501023. ISSN 1433-7851. PMID 16267872. Wikidata Q34465021.
  • Frédéric H Vaillancourt; Ellen Yeh; David A Vosburg; Sylvie Garneau-Tsodikova; Christopher T Walsh (1 August 2006). "Nature's inventory of halogenation catalysts: oxidative strategies predominate". Chemical Reviews. 106 (8): 3364–3378. doi:10.1021/CR050313I. ISSN 0009-2665. PMID 16895332. Wikidata Q34555225.
  • Sylvie Garneau; Nathaniel I Martin; John C Vederas (1 May 2002). "Two-peptide bacteriocins produced by lactic acid bacteria". Biochimie. 84 (5–6): 577–592. doi:10.1016/S0300-9084(02)01414-1. ISSN 0300-9084. PMID 12423802. Wikidata Q34992720.

References
  1. "Sylvie Garneau-Tsodikova". UK College of Pharmacy. Retrieved 2021-04-17.
  2. Garneau, Sylvie (1998). Synthèse d'inhibiteurs de la glutamyl t-ARN synthétase et approche à la synthèse du striatène (Thesis) (in French). Ottawa: National Library of Canada = Bibliothèque nationale du Canada. OCLC 46552296.
  3. Garneau, Sylvie (2004). New antimicrobial agents acting on bacterial cell walls (Thesis). Ottawa: National Library of Canada = Bibliothèque nationale du Canada. OCLC 56752162.
  4. Howard, Kaitlind C.; Dennis, Emily K.; Watt, David S.; Garneau-Tsodikova, Sylvie (2020-04-27). "A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise". Chemical Society Reviews. 49 (8): 2426–2480. doi:10.1039/C9CS00556K. ISSN 1460-4744. PMID 32140691. S2CID 212567513.
  5. "Sylvie Garneau-Tsodikova On Women In STEM". BioTechniques. 2020-03-24. Retrieved 2021-04-17.
  6. "Sylvie Garneau-Tsodikova | Faculty History Project". faculty-history.dc.umich.edu. Retrieved 2021-04-17.
  7. "Sylvie Garneau-Tsodikova, PhD", University of Kentucky, College of Pharmacy. Retrieved May 16, 2020.
  8. "RSC Medicinal Chemistry Desktop Seminar Series". www.rsc.org. Retrieved 2021-04-17.
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