TIMP3

Metalloproteinase inhibitor 3 is a protein that in humans is encoded by the TIMP3 gene.[5][6]

TIMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTIMP3, HSMRK222, K222, K222TA2, SFD, TIMP metallopeptidase inhibitor 3
External IDsOMIM: 188826 MGI: 98754 HomoloGene: 36322 GeneCards: TIMP3
Orthologs
SpeciesHumanMouse
Entrez

7078

21859

Ensembl

ENSG00000100234

ENSMUSG00000020044

UniProt

P35625

P39876

RefSeq (mRNA)

NM_000362

NM_011595

RefSeq (protein)

NP_000353

NP_035725

Location (UCSC)Chr 22: 32.8 – 32.86 MbChr 10: 86.14 – 86.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy.[7]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000100234 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000020044 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Apte SS, Mattei MG, Olsen BR (Jun 1994). "Cloning of the cDNA encoding human tissue inhibitor of metalloproteinases-3 (TIMP-3) and mapping of the TIMP3 gene to chromosome 22". Genomics. 19 (1): 86–90. doi:10.1006/geno.1994.1016. PMID 8188246.
  6. Qi JH, Ebrahem Q, Moore N, Murphy G, Claesson-Welsh L, Bond M, Baker A, Anand-Apte B (Apr 2003). "A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2". Nat Med. 9 (4): 407–15. doi:10.1038/nm846. PMID 12652295. S2CID 12563403.
  7. "Entrez Gene: TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory)".

Further reading

  • The MEROPS online database for peptidases and their inhibitors: I35.003


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