TIMP4

Metalloproteinase inhibitor 4 is an enzyme that in humans is encoded by the TIMP4 gene.[5][6][7]

TIMP4
Identifiers
AliasesTIMP4, TIMP metallopeptidase inhibitor 4, TIMP-4
External IDsOMIM: 601915 MGI: 109125 HomoloGene: 37748 GeneCards: TIMP4
Orthologs
SpeciesHumanMouse
Entrez

7079

110595

Ensembl

ENSG00000157150

ENSMUSG00000030317

UniProt

Q99727

Q9JHB3

RefSeq (mRNA)

NM_003256

NM_080639
NM_001356406

RefSeq (protein)

NP_003247

NP_542370
NP_001343335

Location (UCSC)Chr 3: 12.15 – 12.16 MbChr 6: 115.22 – 115.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

This gene belongs to the tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling.[7]

Interactions

TIMP4 has been shown to interact with MMP2.[8][9]

See also

References

  1. GRCh38: Ensembl release 89: ENSG00000157150 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000030317 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Greene J, Wang M, Liu YE, Raymond LA, Rosen C, Shi YE (Jan 1997). "Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4". J Biol Chem. 271 (48): 30375–30380. doi:10.1074/jbc.271.48.30375. PMID 8939999.
  6. Olson TM, Hirohata S, Ye J, Leco K, Seldin MF, Apte SS (Sep 1998). "Cloning of the human tissue inhibitor of metalloproteinase-4 gene (TIMP4) and localization of the TIMP4 and Timp4 genes to human chromosome 3p25 and mouse chromosome 6, respectively". Genomics. 51 (1): 148–151. doi:10.1006/geno.1998.5362. PMID 9693046.
  7. "Entrez Gene: TIMP4 TIMP metallopeptidase inhibitor 4".
  8. Bigg, H F; Shi Y E; Liu Y E; Steffensen B; Overall C M (Jun 1997). "Specific, high affinity binding of tissue inhibitor of metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like domain of human gelatinase A. TIMP-4 binds progelatinase A and the COOH-terminal domain in a similar manner to TIMP-2". J. Biol. Chem. 272 (24): 15496–15500. doi:10.1074/jbc.272.24.15496. ISSN 0021-9258. PMID 9182583.
  9. Kai, Heidi S-T; Butler Georgina S; Morrison Charlotte J; King Angela E; Pelman Gayle R; Overall Christopher M (Dec 2002). "Utilization of a novel recombinant myoglobin fusion protein expression system to characterize the tissue inhibitor of metalloproteinase (TIMP)-4 and TIMP-2 C-terminal domain and tails by mutagenesis. The importance of acidic residues in binding the MMP-2 hemopexin C-domain". J. Biol. Chem. 277 (50): 48696–48707. doi:10.1074/jbc.M209177200. ISSN 0021-9258. PMID 12374789.

Further reading

  • The MEROPS online database for peptidases and their inhibitors: I35.004
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