tRNA-pseudouridine synthase I

In enzymology, a tRNA-pseudouridine synthase I (EC 5.4.99.12) is an enzyme that catalyzes the chemical reaction

tRNA uridine tRNA pseudouridine
tRNA-pseudouridine synthase
Identifiers
EC no.5.4.99.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, tRNA uridine, and one product, tRNA pseudouridine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is tRNA-uridine uracilmutase. Other names in common use include tRNA-uridine isomerase, tRNA pseudouridylate synthase I, transfer ribonucleate pseudouridine synthetase, pseudouridine synthase, and transfer RNA pseudouridine synthetase.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1VS3, 2NQP, 2NR0, and 2NRE.

References

    • Arena F, Ciliberto G, Ciampi S, Cortese R (1978). "Purification of pseudouridylate synthetase I from Salmonella typhimurium". Nucleic Acids Res. 5 (12): 4523–36. doi:10.1093/nar/5.12.4523. PMC 342770. PMID 370771.
    • Kammen HO, Marvel CC, Hardy L, Penhoet EE (1988). "Purification, structure, and properties of Escherichia coli tRNA pseudouridine synthase I". J. Biol. Chem. 263 (5): 2255–63. doi:10.1016/S0021-9258(18)69199-9. PMID 3276686.


    This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.