TRNA pseudouridine38/39 synthase

tRNA pseudouridine38/39 synthase (EC 5.4.99.45, Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine38/39 uracil mutase.[1][2] This enzyme catalyses the following chemical reaction

tRNA uridine38/39 tRNA pseudouridine38/39
tRNA pseudouridine38/39 synthase
Identifiers
EC no.5.4.99.45
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39.

See also

References

  1. Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H (January 1998). "Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop". The Journal of Biological Chemistry. 273 (3): 1316–23. doi:10.1074/jbc.273.3.1316. PMID 9430663.
  2. Chen J, Patton JR (October 2000). "Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA". Biochemistry. 39 (41): 12723–30. doi:10.1021/bi001109m. PMID 11027153.
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