TRNA pseudouridine38/39 synthase
tRNA pseudouridine38/39 synthase (EC 5.4.99.45, Deg1, Pus3p, pseudouridine synthase 3) is an enzyme with systematic name tRNA-uridine38/39 uracil mutase.[1][2] This enzyme catalyses the following chemical reaction
- tRNA uridine38/39 tRNA pseudouridine38/39
| tRNA pseudouridine38/39 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.45 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme from Saccharomyces cerevisiae is active only towards uridine38 and uridine39.
References
- Lecointe F, Simos G, Sauer A, Hurt EC, Motorin Y, Grosjean H (January 1998). "Characterization of yeast protein Deg1 as pseudouridine synthase (Pus3) catalyzing the formation of psi 38 and psi 39 in tRNA anticodon loop". The Journal of Biological Chemistry. 273 (3): 1316–23. doi:10.1074/jbc.273.3.1316. PMID 9430663.
- Chen J, Patton JR (October 2000). "Pseudouridine synthase 3 from mouse modifies the anticodon loop of tRNA". Biochemistry. 39 (41): 12723–30. doi:10.1021/bi001109m. PMID 11027153.
External links
- TRNA+pseudouridine38/39+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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