Tennessee State Route 107

SR 107 begins as a secondary highway in Cocke County near the North Carolina border at an intersection with Ground Squirrel Road and Round Mountain Road, where the road continues as Round Mountain Road in North Carolina. SR 107 goes northwest through narrow valley and mountains to enter Del Rio, where it crosses a bridge over the French Broad River and becomes concurrent with US 25/US 70/SR 9. They then go east to leave Del Rio and parallel the river to an intersection where SR 107 splits off and goes north. The highway then passes through a rugged and remote part of the Cherokee National Forest before crossing into Greene County.

SR 107 then levels out and passes through Houston Valley before entering South Greene and becoming concurrent with SR 70. They then turn northwest and have an intersection with SR 351 and SR-107 Cutoff. The highway then leaves South Greene and crosses over the Nolichucky River just yards from the historic Nolichucky Dam and Davy Crockett Lake. SR 70/SR 107 then continue north into Greeneville where they come to an intersection with US 321/SR 35, where SR 107 leaves SR 70 to become concurrent with US 321/SR 35 to enter downtown. They then have a short concurrency with SR 350 before becoming concurrent US 11E Bus. They continue north through downtown before US 321/SR 35 splits off and goes north while US 11E Bus/SR 107 continue through town before coming to an intersection with US 11E/US 321/SR 34, where US 11E Bus ends and SR 107 becomes concurrent with that highway as they enter the neighboring town of Tusculum. They then have an intersection with Erwin Highway (Former SR 107 through downtown) before bypassing downtown to the north. They then come to an intersection where SR 107 splits off and goes southeast, becoming a primary highway and leaving Tusculum. SR 107 then enters farmland, where it crosses another bridge over the Nolichucky River and has an intersection with SR 351/SR-107 Cutoff, where SR-107 Cutoff ends and SR 107 becomes concurrent with SR 351. SR 351 then turns north and SR 107 continues east to cross into Washington County.

SR 107 then passes through South Central, where it has an intersection with SR 353, before continuing east, then northeast, paralleling the Nolichucky River. The highway then enters Lamar, where it becomes concurrent with SR 81, before leaving Lamar and crossing another bridge over the Nolichucky River, in the community of Embreeville, and crossing into Unicoi County.

SR 107/SR 81 then pass through a set of mountains before entering Erwin, where they have an interchange with I-26/US 23/US 19W (Exit 37), where SR 81 ends and SR 107 becomes a secondary highway. The highway then enters downtown and then turns left to cross a new bridge over the rail road tracks before leaving downtown and continuing northeast after turning back onto its former alignment. SR 107 then passes through a major business district, where it has an intersection with SR 395 before having an intersection with Harris Hollow Road, which provides access to an interchange with I-26. SR 107 then leaves Erwin and continues northeast to the town of Unicoi, where it becomes concurrent with SR 173. The highway then winds its way between some mountains to enter Limestone Cove, where SR 173 splits off and goes north while SR 107 continues east to enter the Cherokee National Forest. The highway then becomes very curvy coming to the North Carolina state line, where SR 107 ends and continues east as NC 226.