Tilomisole

Tilomisole
Names
	Preferred IUPAC name [3-(4-Chlorophenyl)[1,3]thiazolo[3,2-a] [1,3]benzimidazol-2-yl]acetic acid
Identifiers
CAS Number	58433-11-7;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL2104737;
ChemSpider	38987;
KEGG	D06148;
PubChem CID	42747;
UNII	651G60U372 ;
CompTox Dashboard (EPA)	DTXSID40207137 ;
	InChI InChI=1S/C17H11ClN2O2S/c18-11-7-5-10(6-8-11)16-14(9-15(21)22)23-17-19-12-3-1-2-4-13(12)20(16)17/h1-8H,9H2,(H,21,22);
	SMILES Clc4ccc(c1c(sc2nc3ccccc3n12)CC(=O)O)cc4;
Properties
Chemical formula	C17H11ClN2O2S
Molar mass	342.80
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Tilomisole (WY-18,251) is an experimental drug which acts as an immunomodulator and has been studied for the treatment of some forms of cancer.[1][2]

It can also be seen to contain the arylacetic acid moiety that is endemic to many NSAIDs, e.g. ibufenac.

References

Fenichel RL, Alburn HE, Schreck PA, Bloom R, Gregory FJ (1980). "Immunomodulating and antimetastatic activity of 3-(p-chlorophenyl) thiazolo[3,2-a]benzimidazole-2-acetic acid (Wy-18,251, NSC 310633)". Journal of Immunopharmacology. 2 (4): 491–508. doi:10.3109/08923978009026408. PMID 6970786.
Dillman RO, Ryan KP, Dillman JB, Shawler DL, Maguire R (March 1992). "WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients". Molecular Biotherapy. 4 (1): 10–4. PMID 1385709.

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[pmid6970786-1] Fenichel RL, Alburn HE, Schreck PA, Bloom R, Gregory FJ (1980). "Immunomodulating and antimetastatic activity of 3-(p-chlorophenyl) thiazolo[3,2-a]benzimidazole-2-acetic acid (Wy-18,251, NSC 310633)". Journal of Immunopharmacology. 2 (4): 491–508. doi:10.3109/08923978009026408. PMID 6970786.

[pmid1385709-2] Dillman RO, Ryan KP, Dillman JB, Shawler DL, Maguire R (March 1992). "WY 18,251 (Tilomisole), an analog of levamisole: tolerability, and immune modulating effects in cancer patients". Molecular Biotherapy. 4 (1): 10–4. PMID 1385709.