Tobramycin/dexamethasone

Tobramycin/dexamethasone, sold under the brand name Tobradex, is a fixed-dose combination medication in the form of eye drops and eye ointment, marketed by Alcon.[1][2][3] The active ingredients are tobramycin (an antibiotic) and dexamethasone (a corticosteroid).[2] It is prescribed for the treatment of pink eye in combination with bacterial infections.[2]

Tobramycin/dexamethasone
Combination of
TobramycinAminoglycoside antibiotic
DexamethasoneGlucocorticoid
Clinical data
Trade namesTobradex
AHFS/Drugs.comProfessional Drug Facts
Routes of
administration		Eye drops, topical
ATC code
Legal status
Legal status
Identifiers
CAS Number
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
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Contraindications

It is contraindicated with herpetic and other viral eye infections. Other contraindications include fungal and mycobacterial infections because tobramycin is inactive against those, and the corticoid acts as an immunosuppressive agent, preventing the body's immune system from dealing with the infection. The drops are also contraindicated in patients with corneal lesions.[4][1][2][3]

Side effects

Similarly to other corticosteroid eye drops, side effects include hypersensitivity and, especially after long-term use, secondary eye infections, cataract (clouding of the eye lens) and increased intraocular pressure, leading to glaucoma. Consequently, the drug should not be applied longer than 24 days[4][5][6] without further medical evaluation.[2][3]

Interactions

Anticholinergic eye drops potentiate the risk of increased intraocular pressure. Systemic aminoglycoside antibiotics increase toxicity for ears, nerves and kidney.[4]

Brand names

Tobrason is a brand name in Jordan.[7]

References
  1. "Tobradex- tobramycin and dexamethasone ointment". DailyMed. 24 April 2020. Retrieved 24 September 2020.
  2. "Tobradex- tobramycin and dexamethasone suspension/ drops". DailyMed. 24 April 2020. Retrieved 24 September 2020.
  3. "Tobradex ST- tobramycin / dexamethasone suspension/ drops". DailyMed. 9 September 2019. Retrieved 24 September 2020.
  4. Haberfeld H, ed. (2009). Austria-Codex (in German) (2009/2010 ed.). Vienna: Österreichischer Apothekerverlag. Tobradex-Augentropfen. ISBN 978-3-85200-196-8.
  5. Faschinger C (3 January 2011). "TobraDex". Österreichische Apothekerzeitung (in German) (1/2011): 13.
  6. Dinnendahl V, Fricke U, eds. (2010). Arzneistoff-Profile (in German). Vol. 2 (23 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.
  7. "Jordanian Food and Drug Administration".
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