Transmembrane protein 175
Transmembrane protein 175, or TMEM175, is a transmembrane protein that is thought to be an endolysosomal potassium channel. It is predicted to have many orthologs across eukaryotes.
| Transmembrane protein 175 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TMEM175 | ||||||||
| Pfam | PF06736 | ||||||||
| InterPro | IPR010617 | ||||||||
| TCDB | 1.A.78 | ||||||||
| OPM superfamily | 467 | ||||||||
| OPM protein | 5vre | ||||||||
| |||||||||
| Transmembrane protein 175 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TMEM175 | ||||||
| Alt. symbols | MGC4618 | ||||||
| NCBI gene | 84286 | ||||||
| HGNC | 28709 | ||||||
| RefSeq | NM_032326 | ||||||
| UniProt | Q9BSA9 | ||||||
| Other data | |||||||
| Locus | Chr. 4 p16.3 | ||||||
| |||||||
Expression
Based on human and mouse EST profiles and a human tissue GEO profile, TMEM175 appears to be expressed at a relatively high level (75-98%) in normal tissues.[1][2] TMEM175 appears to be down regulated in stage three ovarian cancer[3]
Homology
Transmembrane protein 175 has no paralogs. It does have orthologs within eukaryotes. The following table presents some of the orthologs found using searches in BLAST[4] and BLAT.[5] This list does not contain all of the orthologs for TMEM175. It is meant to display the diversity of species for which orthologs are found.
| Scientific name | Common Name | Accession Number | Sequence Length | Percent Identity | Percent Similarity |
|---|---|---|---|---|---|
| Homo Sapiens | Human | NP_115702.1 | 504 | - | - |
| Pan troglodytes | Chimp | XP_001141076 | 504 | 92 | 93 |
| Pongo abelii | Orangutan | XP_002814537 | 231 | 99 | 99 |
| Macaca mulatta | Rhesus | XP_001085173.1 | 403 | 96 | 98 |
| Callithrix jacchus | Marmoset | XP_002746113.1 | 472 | 83 | 87 |
| Bos taurus | Cow | NP_001069081.1 | 479 | 77 | 82 |
| Ailuropoda melanoleuca | Panda | XP_002924455.1 | 498 | 81 | 87 |
| Equus caballus | Horse | XP_001488271.1 | 499 | 81 | 86 |
| Rattus norvegicus | Rat | NP_001014013.1 | 499 | 82 | 88 |
| Mus musculus | Mouse | NP_082499.3 | 499 | 81 | 88 |
| Monodelphis domestica | Opossum | XP_001377424.1 | 502 | 67 | 80 |
| Ornithorhynchus anatinus | Platypus | XP_001514176 | 499 | 68 | 82 |
| Gallus gallus | Chicken | NP_001006582.1 | 501 | 64 | 78 |
| Sceloporus occidentalis | Lizard | - | 417 | 56 | 66 |
| Taeniopygia guttata | Zebra Finch | XP_002187908.1 | 496 | 66 | 79 |
| Danio rerio | Zebra Fish | NP_001093545.1 | 520 | 62 | 76 |
| Branchiostoma floridae | Lancelet | XP_002596272 | 409 | 31 | 50 |
| Ciona intestinalis | Sea Squirt | XP_002122718 | 494 | 27 | 50 |
| Nematostella vectensis | Starlet Sea Anemone | XP_001630719 | 489 | 28 | 49 |
Predicted Post-Translational Modification
Using various tools at ExPASy[6] the following are possible post-translational modifications for TMEM175.
- 5 possible CK2 phosphorylation sites
- 2 possible PKC phosphorylation sites
- N-myristoylation sites around transmembrane regions
The N-myristoylation sites are conserved in vertebrates.
References
- EST Profile Viewer- Human
- EST Profile Viewer- Mouse
- [Partheen K, Levan K, Osterberg L, Horvath G (November 2006). "Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors". European Journal of Cancer. 42 (16): 2846–54. doi:10.1016/j.ejca.2006.06.026. PMID 16996261.
- NCBI BLAST: Basic Local Alignment Search Tool
- BLAT Search Genome
- ExPASy Proteomics Server
Further reading
- "Genetic study of Lewy body dementia supports ties to Alzheimer's and Parkinson's diseases". National Institutes of Health (NIH). 2021-02-16. Retrieved 2023-08-07.