Transmembrane protein 222

Transmembrane protein 222 is a protein that in humans is encoded by the TMEM222 gene.[5][6] One notable feature of the protein encoded by this gene is the presence of three predicted transmembrane domains.[7] The TMEM222 protein is predicted to most likely localize to the secretory vesicles.[8]

TMEM222
Identifiers
AliasesTMEM222, C1orf160, transmembrane protein 222, NEDMOSBA
External IDsMGI: 1098568 HomoloGene: 11999 GeneCards: TMEM222
Orthologs
SpeciesHumanMouse
Entrez

84065

52174

Ensembl

ENSG00000186501

ENSMUSG00000028857

UniProt

Q9H0R3

Q8BVA2

RefSeq (mRNA)

NM_032125

NM_025667

RefSeq (protein)

NP_115501

NP_079943

Location (UCSC)Chr 1: 27.32 – 27.34 MbChr 4: 132.99 – 133.01 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Gene Features

TMEM222 has a domain of unknown function (DUF778).[9] Aliases of this gene include DKFZP564D0478, RP11-4K3__A.4, C1orf160, and MGC111002.[10] Accession NM_032125.2, the longest coding sequence (1629 bp), encodes a protein of 208 amino acid residues (23230 Daltons), which is considered the consensus coding sequence (CCDS297.2).[11] There are two isoforms of the protein encoded by this gene. They are similar except the second (Q9H0R3-2) is lacking the first 96 amino acid residues that are present in the first (Q9H0R3-1).[12]

Gene Expression

ACEVIEW has labeled TMEM222 as highly expressed with 3.8 times more expression than the average gene in the database.[13] There is expression evidence from 166 tissues including brain, lung, colon, kidney, and placenta.[13]

Homology

Orthologs and distant homologs of the human TMEM222 have been identified throughout Eukaryota especially in plants and animals.[14] No paralogs of this gene have been found in the human genome.[15]

Genus/SpeciesCommon NameAccession NumberLengthSimilarityIdentity
Rattus norvegicusRatNP_001107252.1 208aa99%96%
Canis familiarisDogXP_852505.1 208aa98%96%
Mus musculusMouseNP_079943.2 208aa96%95%
Sus scrofaPigXP_003127773.1 208aa97%94%
Equus caballusHorseXP_001917747.1 207aa94%93%
Gallus gallusChickenXP_417729.1 182aa90%85%
Danio rerioZebrafishNP_001013334.1 174aa83%71%
Anopheles gambiaeMosquitoXP_320483.3 197aa66%53%
Drosophila melanogasterFruit FlyNP_723362.1196aa74%61%
Caenorhabditis elegansNematodeNP_494762.2168aa72%55%
Phytophthora infestansLate BlightXP_002902629.1186aa59%48%
Zea maysCornNP_001144071.1233aa61%44%
Oryza sativaRiceNP_001051577.1 204aa61%43%
Arabidopsis thalianaThall cressNP_190673.1231aa55%36%
Homo sapiensHumanNP_115501.2208--

Distant Homolog

A distant homolog of TMEM222,[14] RTH (RTE1-Homolog),[16] is a homolog of RTE1 (Reversion-to-Ethylene Perception 1), which is known to induce conformational changes in ETR1 (Ethylene receptor 1) that result in negative regulation corresponding with loss of ethylene perception.[17]

Protein Interactions

Evidence from yeast two-hybrid screening exists for two protein interactions with this gene. One is a serine protease (PRSS23)[18] that has been identified to be involved in mouse ovulation and is excreted into the extracellular matrix.[19] The other protein is an ab-hydrolase (HLA-B associated transcript 5)[20] that is integral to the membrane, and its corresponding gene is located in the genome near Tumor Necrosis Factor (TNF)-alpha and TNF-beta.[21]

References

  1. GRCh38: Ensembl release 89: ENSG00000186501 - Ensembl, May 2017
  2. GRCm38: Ensembl release 89: ENSMUSG00000028857 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. "Entrez Gene: C1orf160 chromosome 1 open reading frame 160".
  7. TMHMM
  8. k-NN
  9. NCBI (National Center for Biotechnology information)
  10. Gene Cards
  11. Uniprot
  12. Uniprot
  13. ACEVIEW
  14. Homologene
  15. BLAST
  16. "RTH RTE1-homolog [Arabidopsis thaliana (thale cress)] - Gene - NCBI".
  17. Resnick JS, Wen CK, Shockey JA, Chang C (May 2006). "REVERSION-TO-ETHYLENE SENSITIVITY1, a conserved gene that regulates ethylene receptor function in Arabidopsis". Proc. Natl. Acad. Sci. U.S.A. 103 (20): 7917–22. doi:10.1073/pnas.0602239103. PMC 1458508. PMID 16682642.
  18. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (September 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  19. Miyakoshi K, Murphy MJ, Yeoman RR, Mitra S, Dubay CJ, Hennebold JD (December 2006). "The identification of novel ovarian proteases through the use of genomic and bioinformatic methodologies". Biol. Reprod. 75 (6): 823–35. doi:10.1095/biolreprod.106.052290. PMID 16870946.
  20. Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (January 2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
  21. Spies T, Bresnahan M, Strominger JL (November 1989). "Human major histocompatibility complex contains a minimum of 19 genes between the complement cluster and HLA-B". Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8955–8. Bibcode:1989PNAS...86.8955S. doi:10.1073/pnas.86.22.8955. PMC 298409. PMID 2813433.

Further reading

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