Tyrosine 2,3-aminomutase

In enzymology, a tyrosine 2,3-aminomutase (EC 5.4.3.6) is an enzyme that catalyzes the chemical reaction[1]

L-tyrosine 3-amino-3-(4-hydroxyphenyl)propanoate
tyrosine 2,3-aminomutase
Identifiers
EC no.5.4.3.6
CAS no.9073-38-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Hence, this enzyme has one substrate, L-tyrosine, and one product, 3-amino-3-(4-hydroxyphenyl)propanoate.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is L-tyrosine 2,3-aminomutase. This enzyme is also called tyrosine alpha,beta-mutase. This enzyme participates in tyrosine metabolism. It employs one cofactor, 5-methylene-3,5-dihydroimidazol-4-one (MIO) which is formed autocatalytic rearrangement of the internal tripeptide Ala-Ser-Gly.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2OHY.

References

  1. Kurylo-Borowska Z, Abramsky T (1972). "Biosynthesis of β-tyrosine". Biochim. Biophys. Acta. 264 (1): 1–10. doi:10.1016/0304-4165(72)90110-9. PMID 5021987.


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