UDP-galactose—UDP-N-acetylglucosamine galactose phosphotransferase

In enzymology, an UDP-galactose—UDP-N-acetylglucosamine galactose phosphotransferase (EC 2.7.8.18) is an enzyme that catalyzes the chemical reaction

UDP-galactose + UDP-N-acetyl-D-glucosamine UMP + UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine
UDP-galactose-UDP-N-acetylglucosamine galactose phosphotransferase
Identifiers
EC no.2.7.8.18
CAS no.84932-43-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
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NCBIproteins

Thus, the two substrates of this enzyme are UDP-galactose and UDP-N-acetyl-D-glucosamine, whereas its two products are UMP and UDP-N-acetyl-6-(D-galactose-1-phospho)-D-glucosamine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups transferases for other substituted phosphate groups. The systematic name of this enzyme class is UDP-galactose:UDP-N-acetyl-D-glucosamine galactose phosphotransferase. Other names in common use include uridine diphosphogalactose-uridine diphosphoacetylglucosamine galactose-1-phosphotransferase, galactose-1-phosphotransferase, and galactosyl phosphotransferase.

References

    • Nakanishi Y, Otsu K, Suzuki S (1983). "Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine". FEBS Lett. 151 (1): 15–8. doi:10.1016/0014-5793(83)80332-9. PMID 6130977.


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