UDP-glucose—glycoprotein glucose phosphotransferase

In enzymology, an UDP-glucose—glycoprotein glucose phosphotransferase (EC 2.7.8.19) is an enzyme that catalyzes the chemical reaction

UDP-glucose + glycoprotein D-mannose UMP + glycoprotein 6-(D-glucose-1-phospho)-D-mannose
UDP-glucose-glycoprotein glucose phosphotransferase
Identifiers
EC no.2.7.8.19
CAS no.84861-40-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
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PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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Thus, the two substrates of this enzyme are UDP-glucose and glycoprotein D-mannose, whereas its two products are UMP and glycoprotein 6-(D-glucose-1-phospho)-D-mannose.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is UDP-glucose:glycoprotein-D-mannose glucosephosphotransferase. Other names in common use include UDP-glucose:glycoprotein glucose-1-phosphotransferase, GlcPTase, Glc-phosphotransferase, and uridine diphosphoglucose-glycoprotein glucose-1-phosphotransferase.

References

    • Koro LA, Marchase RB (1982). "A UDP-glucose:glycoprotein glucose-1-phosphotransferase in embryonic chicken neural retina". Cell. 31 (3 Pt 2): 739–48. doi:10.1016/0092-8674(82)90328-2. PMID 6297779.


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